High-throughput discovery of novel developmental phenotypes.
Identifieur interne : 000037 ( France/Analysis ); précédent : 000036; suivant : 000038High-throughput discovery of novel developmental phenotypes.
Auteurs : Mary E. Dickinson [États-Unis] ; Ann M. Flenniken [Canada] ; Xiao Ji [États-Unis] ; Lydia Teboul [Royaume-Uni] ; Michael D. Wong [Canada] ; Jacqueline K. White [Royaume-Uni] ; Terrence F. Meehan [Royaume-Uni] ; Wolfgang J. Weninger [Autriche] ; Henrik Westerberg [Royaume-Uni] ; Hibret Adissu [Canada] ; Candice N. Baker [États-Unis] ; Lynette Bower [États-Unis] ; James M. Brown [Royaume-Uni] ; L Brianna Caddle [États-Unis] ; Francesco Chiani [Italie] ; Dave Clary [États-Unis] ; James Cleak [Royaume-Uni] ; Mark J. Daly [États-Unis] ; James M. Denegre [États-Unis] ; Brendan Doe [Royaume-Uni] ; Mary E. Dolan [États-Unis] ; Sarah M. Edie [États-Unis] ; Helmut Fuchs [Allemagne] ; Valerie Gailus-Durner [Allemagne] ; Antonella Galli [Royaume-Uni] ; Alessia Gambadoro [Italie] ; Juan Gallegos [États-Unis] ; Shiying Guo [République populaire de Chine] ; Neil R. Horner [Royaume-Uni] ; Chih-Wei Hsu [États-Unis] ; Sara J. Johnson [Royaume-Uni] ; Sowmya Kalaga [États-Unis] ; Lance C. Keith [États-Unis] ; Louise Lanoue [États-Unis] ; Thomas N. Lawson [Royaume-Uni] ; Monkol Lek [États-Unis] ; Manuel Mark [France] ; Susan Marschall [Allemagne] ; Jeremy Mason [Royaume-Uni] ; Melissa L. Mcelwee [États-Unis] ; Susan Newbigging [Canada] ; Lauryl M J. Nutter [Canada] ; Kevin A. Peterson [États-Unis] ; Ramiro Ramirez-Solis [Royaume-Uni] ; Douglas J. Rowland [États-Unis] ; Edward Ryder [Royaume-Uni] ; Kaitlin E. Samocha [États-Unis] ; John R. Seavitt [États-Unis] ; Mohammed Selloum [France] ; Zsombor Szoke-Kovacs [Royaume-Uni] ; Masaru Tamura [Japon] ; Amanda G. Trainor [États-Unis] ; Ilinca Tudose [Royaume-Uni] ; Shigeharu Wakana [Japon] ; Jonathan Warren [Royaume-Uni] ; Olivia Wendling [France] ; David B. West [États-Unis] ; Leeyean Wong [États-Unis] ; Atsushi Yoshiki [Japon] ; Daniel G. Macarthur [États-Unis] ; Glauco P. Tocchini-Valentini [Italie] ; Xiang Gao [République populaire de Chine] ; Paul Flicek [Royaume-Uni] ; Allan Bradley [Royaume-Uni] ; William C. Skarnes [Royaume-Uni] ; Monica J. Justice [Canada] ; Helen E. Parkinson [Royaume-Uni] ; Mark Moore [États-Unis] ; Sara Wells [Royaume-Uni] ; Robert E. Braun [États-Unis] ; Karen L. Svenson [États-Unis] ; Martin Hrabe De Angelis [Allemagne] ; Yann Herault [France] ; Tim Mohun [Royaume-Uni] ; Ann-Marie Mallon [Royaume-Uni] ; R Mark Henkelman [Canada] ; Steve D M. Brown [Royaume-Uni] ; David J. Adams [Royaume-Uni] ; K C Kent Lloyd [États-Unis] ; Colin Mckerlie [Canada] ; Arthur L. Beaudet [États-Unis] ; Maja Bu An [États-Unis] ; Stephen A. Murray [États-Unis]Source :
- Nature [ 1476-4687 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Conserved Sequence (genetics), Disease, Embryo, Mammalian (embryology), Embryo, Mammalian (metabolism), Genes, Essential (genetics), Genes, Lethal (genetics), Genome-Wide Association Study, High-Throughput Screening Assays, Humans, Imaging, Three-Dimensional, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation (genetics), Penetrance, Phenotype, Polymorphism, Single Nucleotide (genetics), Sequence Homology.
- MESH :
- embryology : Embryo, Mammalian.
- genetics : Conserved Sequence, Genes, Essential, Genes, Lethal, Mutation, Polymorphism, Single Nucleotide.
- metabolism : Embryo, Mammalian.
- Animals, Disease, Genome-Wide Association Study, High-Throughput Screening Assays, Humans, Imaging, Three-Dimensional, Mice, Mice, Inbred C57BL, Mice, Knockout, Penetrance, Phenotype, Sequence Homology.
Abstract
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,000 knockout mouse lines, here we identify 410 lethal genes during the production of the first 1,751 unique gene knockouts. Using a standardized phenotyping platform that incorporates high-resolution 3D imaging, we identify phenotypes at multiple time points for previously uncharacterized genes and additional phenotypes for genes with previously reported mutant phenotypes. Unexpectedly, our analysis reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background. In addition, we show that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts.
DOI: 10.1038/nature19356
PubMed: 27626380
Affiliations:
- Allemagne, Autriche, Canada, France, Italie, Japon, Royaume-Uni, République populaire de Chine, États-Unis
- Alsace (région administrative), Grand Est, Vienne (Autriche)
- Vienne (Autriche)
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pubmed:27626380Le document en format XML
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Flenniken</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Ji, Xiao" sort="Ji, Xiao" uniqKey="Ji X" first="Xiao" last="Ji">Xiao Ji</name><affiliation wicri:level="1"><nlm:affiliation>Genomics and Computational Biology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomics and Computational Biology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Teboul, Lydia" sort="Teboul, Lydia" uniqKey="Teboul L" first="Lydia" last="Teboul">Lydia Teboul</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Michael D" sort="Wong, Michael D" uniqKey="Wong M" first="Michael D" last="Wong">Michael D. 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Weninger</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Anatomy and Cell Biology, Medical University of Vienna, Vienna A-1090, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Centre for Anatomy and Cell Biology, Medical University of Vienna, Vienna A-1090</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Westerberg, Henrik" sort="Westerberg, Henrik" uniqKey="Westerberg H" first="Henrik" last="Westerberg">Henrik Westerberg</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Adissu, Hibret" sort="Adissu, Hibret" uniqKey="Adissu H" first="Hibret" last="Adissu">Hibret Adissu</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Baker, Candice N" sort="Baker, Candice N" uniqKey="Baker C" first="Candice N" last="Baker">Candice N. Baker</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Bower, Lynette" sort="Bower, Lynette" uniqKey="Bower L" first="Lynette" last="Bower">Lynette Bower</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Brown, James M" sort="Brown, James M" uniqKey="Brown J" first="James M" last="Brown">James M. Brown</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Caddle, L Brianna" sort="Caddle, L Brianna" uniqKey="Caddle L" first="L Brianna" last="Caddle">L Brianna Caddle</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Chiani, Francesco" sort="Chiani, Francesco" uniqKey="Chiani F" first="Francesco" last="Chiani">Francesco Chiani</name><affiliation wicri:level="1"><nlm:affiliation>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015</wicri:regionArea><wicri:noRegion>Monterotondo Scalo I-00015</wicri:noRegion></affiliation></author><author><name sortKey="Clary, Dave" sort="Clary, Dave" uniqKey="Clary D" first="Dave" last="Clary">Dave Clary</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Cleak, James" sort="Cleak, James" uniqKey="Cleak J" first="James" last="Cleak">James Cleak</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J" last="Daly">Mark J. Daly</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Denegre, James M" sort="Denegre, James M" uniqKey="Denegre J" first="James M" last="Denegre">James M. Denegre</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Doe, Brendan" sort="Doe, Brendan" uniqKey="Doe B" first="Brendan" last="Doe">Brendan Doe</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Dolan, Mary E" sort="Dolan, Mary E" uniqKey="Dolan M" first="Mary E" last="Dolan">Mary E. Dolan</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Edie, Sarah M" sort="Edie, Sarah M" uniqKey="Edie S" first="Sarah M" last="Edie">Sarah M. Edie</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Fuchs, Helmut" sort="Fuchs, Helmut" uniqKey="Fuchs H" first="Helmut" last="Fuchs">Helmut Fuchs</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Gailus Durner, Valerie" sort="Gailus Durner, Valerie" uniqKey="Gailus Durner V" first="Valerie" last="Gailus-Durner">Valerie Gailus-Durner</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Galli, Antonella" sort="Galli, Antonella" uniqKey="Galli A" first="Antonella" last="Galli">Antonella Galli</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Gambadoro, Alessia" sort="Gambadoro, Alessia" uniqKey="Gambadoro A" first="Alessia" last="Gambadoro">Alessia Gambadoro</name><affiliation wicri:level="1"><nlm:affiliation>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015</wicri:regionArea><wicri:noRegion>Monterotondo Scalo I-00015</wicri:noRegion></affiliation></author><author><name sortKey="Gallegos, Juan" sort="Gallegos, Juan" uniqKey="Gallegos J" first="Juan" last="Gallegos">Juan Gallegos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Shiying" sort="Guo, Shiying" uniqKey="Guo S" first="Shiying" last="Guo">Shiying Guo</name><affiliation wicri:level="1"><nlm:affiliation>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061</wicri:regionArea><wicri:noRegion>Nanjing 210061</wicri:noRegion></affiliation></author><author><name sortKey="Horner, Neil R" sort="Horner, Neil R" uniqKey="Horner N" first="Neil R" last="Horner">Neil R. Horner</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Chih Wei" sort="Hsu, Chih Wei" uniqKey="Hsu C" first="Chih-Wei" last="Hsu">Chih-Wei Hsu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Sara J" sort="Johnson, Sara J" uniqKey="Johnson S" first="Sara J" last="Johnson">Sara J. Johnson</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Kalaga, Sowmya" sort="Kalaga, Sowmya" uniqKey="Kalaga S" first="Sowmya" last="Kalaga">Sowmya Kalaga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Keith, Lance C" sort="Keith, Lance C" uniqKey="Keith L" first="Lance C" last="Keith">Lance C. Keith</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Lanoue, Louise" sort="Lanoue, Louise" uniqKey="Lanoue L" first="Louise" last="Lanoue">Louise Lanoue</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Lawson, Thomas N" sort="Lawson, Thomas N" uniqKey="Lawson T" first="Thomas N" last="Lawson">Thomas N. Lawson</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Lek, Monkol" sort="Lek, Monkol" uniqKey="Lek M" first="Monkol" last="Lek">Monkol Lek</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Mark, Manuel" sort="Mark, Manuel" uniqKey="Mark M" first="Manuel" last="Mark">Manuel Mark</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Marschall, Susan" sort="Marschall, Susan" uniqKey="Marschall S" first="Susan" last="Marschall">Susan Marschall</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Mason, Jeremy" sort="Mason, Jeremy" uniqKey="Mason J" first="Jeremy" last="Mason">Jeremy Mason</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Mcelwee, Melissa L" sort="Mcelwee, Melissa L" uniqKey="Mcelwee M" first="Melissa L" last="Mcelwee">Melissa L. Mcelwee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Newbigging, Susan" sort="Newbigging, Susan" uniqKey="Newbigging S" first="Susan" last="Newbigging">Susan Newbigging</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Nutter, Lauryl M J" sort="Nutter, Lauryl M J" uniqKey="Nutter L" first="Lauryl M J" last="Nutter">Lauryl M J. Nutter</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Peterson, Kevin A" sort="Peterson, Kevin A" uniqKey="Peterson K" first="Kevin A" last="Peterson">Kevin A. Peterson</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Rowland, Douglas J" sort="Rowland, Douglas J" uniqKey="Rowland D" first="Douglas J" last="Rowland">Douglas J. Rowland</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Ryder, Edward" sort="Ryder, Edward" uniqKey="Ryder E" first="Edward" last="Ryder">Edward Ryder</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Samocha, Kaitlin E" sort="Samocha, Kaitlin E" uniqKey="Samocha K" first="Kaitlin E" last="Samocha">Kaitlin E. Samocha</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Seavitt, John R" sort="Seavitt, John R" uniqKey="Seavitt J" first="John R" last="Seavitt">John R. Seavitt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Selloum, Mohammed" sort="Selloum, Mohammed" uniqKey="Selloum M" first="Mohammed" last="Selloum">Mohammed Selloum</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Szoke Kovacs, Zsombor" sort="Szoke Kovacs, Zsombor" uniqKey="Szoke Kovacs Z" first="Zsombor" last="Szoke-Kovacs">Zsombor Szoke-Kovacs</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Tamura, Masaru" sort="Tamura, Masaru" uniqKey="Tamura M" first="Masaru" last="Tamura">Masaru Tamura</name><affiliation wicri:level="1"><nlm:affiliation>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074</wicri:regionArea><wicri:noRegion>Ibaraki 305-0074</wicri:noRegion></affiliation></author><author><name sortKey="Trainor, Amanda G" sort="Trainor, Amanda G" uniqKey="Trainor A" first="Amanda G" last="Trainor">Amanda G. Trainor</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Tudose, Ilinca" sort="Tudose, Ilinca" uniqKey="Tudose I" first="Ilinca" last="Tudose">Ilinca Tudose</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Wakana, Shigeharu" sort="Wakana, Shigeharu" uniqKey="Wakana S" first="Shigeharu" last="Wakana">Shigeharu Wakana</name><affiliation wicri:level="1"><nlm:affiliation>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074</wicri:regionArea><wicri:noRegion>Ibaraki 305-0074</wicri:noRegion></affiliation></author><author><name sortKey="Warren, Jonathan" sort="Warren, Jonathan" uniqKey="Warren J" first="Jonathan" last="Warren">Jonathan Warren</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Wendling, Olivia" sort="Wendling, Olivia" uniqKey="Wendling O" first="Olivia" last="Wendling">Olivia Wendling</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="West, David B" sort="West, David B" uniqKey="West D" first="David B" last="West">David B. West</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital Oakland Research Institute, Oakland, California 94609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital Oakland Research Institute, Oakland, California 94609</wicri:regionArea><wicri:noRegion>California 94609</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Leeyean" sort="Wong, Leeyean" uniqKey="Wong L" first="Leeyean" last="Wong">Leeyean Wong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Yoshiki, Atsushi" sort="Yoshiki, Atsushi" uniqKey="Yoshiki A" first="Atsushi" last="Yoshiki">Atsushi Yoshiki</name><affiliation wicri:level="1"><nlm:affiliation>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074</wicri:regionArea><wicri:noRegion>Ibaraki 305-0074</wicri:noRegion></affiliation></author><author><name sortKey="Macarthur, Daniel G" sort="Macarthur, Daniel G" uniqKey="Macarthur D" first="Daniel G" last="Macarthur">Daniel G. Macarthur</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Tocchini Valentini, Glauco P" sort="Tocchini Valentini, Glauco P" uniqKey="Tocchini Valentini G" first="Glauco P" last="Tocchini-Valentini">Glauco P. Tocchini-Valentini</name><affiliation wicri:level="1"><nlm:affiliation>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015</wicri:regionArea><wicri:noRegion>Monterotondo Scalo I-00015</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="1"><nlm:affiliation>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061</wicri:regionArea><wicri:noRegion>Nanjing 210061</wicri:noRegion></affiliation></author><author><name sortKey="Flicek, Paul" sort="Flicek, Paul" uniqKey="Flicek P" first="Paul" last="Flicek">Paul Flicek</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Bradley, Allan" sort="Bradley, Allan" uniqKey="Bradley A" first="Allan" last="Bradley">Allan Bradley</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Skarnes, William C" sort="Skarnes, William C" uniqKey="Skarnes W" first="William C" last="Skarnes">William C. Skarnes</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Justice, Monica J" sort="Justice, Monica J" uniqKey="Justice M" first="Monica J" last="Justice">Monica J. Justice</name><affiliation wicri:level="1"><nlm:affiliation>The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, Toronto, Ontario M5G 1X8</wicri:regionArea><wicri:noRegion>Ontario M5G 1X8</wicri:noRegion></affiliation></author><author><name sortKey="Parkinson, Helen E" sort="Parkinson, Helen E" uniqKey="Parkinson H" first="Helen E" last="Parkinson">Helen E. Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Mark" sort="Moore, Mark" uniqKey="Moore M" first="Mark" last="Moore">Mark Moore</name><affiliation wicri:level="1"><nlm:affiliation>IMPC, San Anselmo, California 94960, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>IMPC, San Anselmo, California 94960</wicri:regionArea><wicri:noRegion>California 94960</wicri:noRegion></affiliation></author><author><name sortKey="Wells, Sara" sort="Wells, Sara" uniqKey="Wells S" first="Sara" last="Wells">Sara Wells</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Braun, Robert E" sort="Braun, Robert E" uniqKey="Braun R" first="Robert E" last="Braun">Robert E. Braun</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Svenson, Karen L" sort="Svenson, Karen L" uniqKey="Svenson K" first="Karen L" last="Svenson">Karen L. Svenson</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="De Angelis, Martin Hrabe" sort="De Angelis, Martin Hrabe" uniqKey="De Angelis M" first="Martin Hrabe" last="De Angelis">Martin Hrabe De Angelis</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Herault, Yann" sort="Herault, Yann" uniqKey="Herault Y" first="Yann" last="Herault">Yann Herault</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Mohun, Tim" sort="Mohun, Tim" uniqKey="Mohun T" first="Tim" last="Mohun">Tim Mohun</name><affiliation wicri:level="1"><nlm:affiliation>The Francis Crick Institute Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW1 1AT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Francis Crick Institute Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW1 1AT</wicri:regionArea><wicri:noRegion>London NW1 1AT</wicri:noRegion></affiliation></author><author><name sortKey="Mallon, Ann Marie" sort="Mallon, Ann Marie" uniqKey="Mallon A" first="Ann-Marie" last="Mallon">Ann-Marie Mallon</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Henkelman, R Mark" sort="Henkelman, R Mark" uniqKey="Henkelman R" first="R Mark" last="Henkelman">R Mark Henkelman</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Steve D M" sort="Brown, Steve D M" uniqKey="Brown S" first="Steve D M" last="Brown">Steve D M. Brown</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Adams, David J" sort="Adams, David J" uniqKey="Adams D" first="David J" last="Adams">David J. Adams</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Lloyd, K C Kent" sort="Lloyd, K C Kent" uniqKey="Lloyd K" first="K C Kent" last="Lloyd">K C Kent Lloyd</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Mckerlie, Colin" sort="Mckerlie, Colin" uniqKey="Mckerlie C" first="Colin" last="Mckerlie">Colin Mckerlie</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Beaudet, Arthur L" sort="Beaudet, Arthur L" uniqKey="Beaudet A" first="Arthur L" last="Beaudet">Arthur L. Beaudet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Bu An, Maja" sort="Bu An, Maja" uniqKey="Bu An M" first="Maja" last="Bu An">Maja Bu An</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Genetics and Psychiatry, Perlman School of Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics and Psychiatry, Perlman School of Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Philadelphia Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Stephen A" sort="Murray, Stephen A" uniqKey="Murray S" first="Stephen A" last="Murray">Stephen A. Murray</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27626380</idno><idno type="pmid">27626380</idno><idno type="doi">10.1038/nature19356</idno><idno type="wicri:Area/PubMed/Corpus">000150</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000150</idno><idno type="wicri:Area/PubMed/Curation">000150</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000150</idno><idno type="wicri:Area/PubMed/Checkpoint">000150</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000150</idno><idno type="wicri:Area/Ncbi/Merge">002085</idno><idno type="wicri:Area/Ncbi/Curation">002085</idno><idno type="wicri:Area/Ncbi/Checkpoint">002085</idno><idno type="wicri:Area/Main/Merge">000331</idno><idno type="wicri:Area/Main/Curation">000330</idno><idno type="wicri:Area/Main/Exploration">000330</idno><idno type="wicri:Area/France/Extraction">000037</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High-throughput discovery of novel developmental phenotypes.</title><author><name sortKey="Dickinson, Mary E" sort="Dickinson, Mary E" uniqKey="Dickinson M" first="Mary E" last="Dickinson">Mary E. Dickinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Flenniken, Ann M" sort="Flenniken, Ann M" uniqKey="Flenniken A" first="Ann M" last="Flenniken">Ann M. Flenniken</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Ji, Xiao" sort="Ji, Xiao" uniqKey="Ji X" first="Xiao" last="Ji">Xiao Ji</name><affiliation wicri:level="1"><nlm:affiliation>Genomics and Computational Biology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomics and Computational Biology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Teboul, Lydia" sort="Teboul, Lydia" uniqKey="Teboul L" first="Lydia" last="Teboul">Lydia Teboul</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Michael D" sort="Wong, Michael D" uniqKey="Wong M" first="Michael D" last="Wong">Michael D. Wong</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="White, Jacqueline K" sort="White, Jacqueline K" uniqKey="White J" first="Jacqueline K" last="White">Jacqueline K. White</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Meehan, Terrence F" sort="Meehan, Terrence F" uniqKey="Meehan T" first="Terrence F" last="Meehan">Terrence F. Meehan</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Weninger, Wolfgang J" sort="Weninger, Wolfgang J" uniqKey="Weninger W" first="Wolfgang J" last="Weninger">Wolfgang J. Weninger</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Anatomy and Cell Biology, Medical University of Vienna, Vienna A-1090, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Centre for Anatomy and Cell Biology, Medical University of Vienna, Vienna A-1090</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Westerberg, Henrik" sort="Westerberg, Henrik" uniqKey="Westerberg H" first="Henrik" last="Westerberg">Henrik Westerberg</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Adissu, Hibret" sort="Adissu, Hibret" uniqKey="Adissu H" first="Hibret" last="Adissu">Hibret Adissu</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Baker, Candice N" sort="Baker, Candice N" uniqKey="Baker C" first="Candice N" last="Baker">Candice N. Baker</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Bower, Lynette" sort="Bower, Lynette" uniqKey="Bower L" first="Lynette" last="Bower">Lynette Bower</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Brown, James M" sort="Brown, James M" uniqKey="Brown J" first="James M" last="Brown">James M. Brown</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Caddle, L Brianna" sort="Caddle, L Brianna" uniqKey="Caddle L" first="L Brianna" last="Caddle">L Brianna Caddle</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Chiani, Francesco" sort="Chiani, Francesco" uniqKey="Chiani F" first="Francesco" last="Chiani">Francesco Chiani</name><affiliation wicri:level="1"><nlm:affiliation>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015</wicri:regionArea><wicri:noRegion>Monterotondo Scalo I-00015</wicri:noRegion></affiliation></author><author><name sortKey="Clary, Dave" sort="Clary, Dave" uniqKey="Clary D" first="Dave" last="Clary">Dave Clary</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Cleak, James" sort="Cleak, James" uniqKey="Cleak J" first="James" last="Cleak">James Cleak</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J" last="Daly">Mark J. Daly</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Denegre, James M" sort="Denegre, James M" uniqKey="Denegre J" first="James M" last="Denegre">James M. Denegre</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Doe, Brendan" sort="Doe, Brendan" uniqKey="Doe B" first="Brendan" last="Doe">Brendan Doe</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Dolan, Mary E" sort="Dolan, Mary E" uniqKey="Dolan M" first="Mary E" last="Dolan">Mary E. Dolan</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Edie, Sarah M" sort="Edie, Sarah M" uniqKey="Edie S" first="Sarah M" last="Edie">Sarah M. Edie</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Fuchs, Helmut" sort="Fuchs, Helmut" uniqKey="Fuchs H" first="Helmut" last="Fuchs">Helmut Fuchs</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Gailus Durner, Valerie" sort="Gailus Durner, Valerie" uniqKey="Gailus Durner V" first="Valerie" last="Gailus-Durner">Valerie Gailus-Durner</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Galli, Antonella" sort="Galli, Antonella" uniqKey="Galli A" first="Antonella" last="Galli">Antonella Galli</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Gambadoro, Alessia" sort="Gambadoro, Alessia" uniqKey="Gambadoro A" first="Alessia" last="Gambadoro">Alessia Gambadoro</name><affiliation wicri:level="1"><nlm:affiliation>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015</wicri:regionArea><wicri:noRegion>Monterotondo Scalo I-00015</wicri:noRegion></affiliation></author><author><name sortKey="Gallegos, Juan" sort="Gallegos, Juan" uniqKey="Gallegos J" first="Juan" last="Gallegos">Juan Gallegos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Shiying" sort="Guo, Shiying" uniqKey="Guo S" first="Shiying" last="Guo">Shiying Guo</name><affiliation wicri:level="1"><nlm:affiliation>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061</wicri:regionArea><wicri:noRegion>Nanjing 210061</wicri:noRegion></affiliation></author><author><name sortKey="Horner, Neil R" sort="Horner, Neil R" uniqKey="Horner N" first="Neil R" last="Horner">Neil R. Horner</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Chih Wei" sort="Hsu, Chih Wei" uniqKey="Hsu C" first="Chih-Wei" last="Hsu">Chih-Wei Hsu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Sara J" sort="Johnson, Sara J" uniqKey="Johnson S" first="Sara J" last="Johnson">Sara J. Johnson</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Kalaga, Sowmya" sort="Kalaga, Sowmya" uniqKey="Kalaga S" first="Sowmya" last="Kalaga">Sowmya Kalaga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Keith, Lance C" sort="Keith, Lance C" uniqKey="Keith L" first="Lance C" last="Keith">Lance C. Keith</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Lanoue, Louise" sort="Lanoue, Louise" uniqKey="Lanoue L" first="Louise" last="Lanoue">Louise Lanoue</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Lawson, Thomas N" sort="Lawson, Thomas N" uniqKey="Lawson T" first="Thomas N" last="Lawson">Thomas N. Lawson</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Lek, Monkol" sort="Lek, Monkol" uniqKey="Lek M" first="Monkol" last="Lek">Monkol Lek</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Mark, Manuel" sort="Mark, Manuel" uniqKey="Mark M" first="Manuel" last="Mark">Manuel Mark</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Marschall, Susan" sort="Marschall, Susan" uniqKey="Marschall S" first="Susan" last="Marschall">Susan Marschall</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Mason, Jeremy" sort="Mason, Jeremy" uniqKey="Mason J" first="Jeremy" last="Mason">Jeremy Mason</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Mcelwee, Melissa L" sort="Mcelwee, Melissa L" uniqKey="Mcelwee M" first="Melissa L" last="Mcelwee">Melissa L. Mcelwee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Newbigging, Susan" sort="Newbigging, Susan" uniqKey="Newbigging S" first="Susan" last="Newbigging">Susan Newbigging</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Nutter, Lauryl M J" sort="Nutter, Lauryl M J" uniqKey="Nutter L" first="Lauryl M J" last="Nutter">Lauryl M J. Nutter</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Peterson, Kevin A" sort="Peterson, Kevin A" uniqKey="Peterson K" first="Kevin A" last="Peterson">Kevin A. Peterson</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Rowland, Douglas J" sort="Rowland, Douglas J" uniqKey="Rowland D" first="Douglas J" last="Rowland">Douglas J. Rowland</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Ryder, Edward" sort="Ryder, Edward" uniqKey="Ryder E" first="Edward" last="Ryder">Edward Ryder</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Samocha, Kaitlin E" sort="Samocha, Kaitlin E" uniqKey="Samocha K" first="Kaitlin E" last="Samocha">Kaitlin E. Samocha</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Seavitt, John R" sort="Seavitt, John R" uniqKey="Seavitt J" first="John R" last="Seavitt">John R. Seavitt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Selloum, Mohammed" sort="Selloum, Mohammed" uniqKey="Selloum M" first="Mohammed" last="Selloum">Mohammed Selloum</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Szoke Kovacs, Zsombor" sort="Szoke Kovacs, Zsombor" uniqKey="Szoke Kovacs Z" first="Zsombor" last="Szoke-Kovacs">Zsombor Szoke-Kovacs</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Tamura, Masaru" sort="Tamura, Masaru" uniqKey="Tamura M" first="Masaru" last="Tamura">Masaru Tamura</name><affiliation wicri:level="1"><nlm:affiliation>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074</wicri:regionArea><wicri:noRegion>Ibaraki 305-0074</wicri:noRegion></affiliation></author><author><name sortKey="Trainor, Amanda G" sort="Trainor, Amanda G" uniqKey="Trainor A" first="Amanda G" last="Trainor">Amanda G. Trainor</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Tudose, Ilinca" sort="Tudose, Ilinca" uniqKey="Tudose I" first="Ilinca" last="Tudose">Ilinca Tudose</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Wakana, Shigeharu" sort="Wakana, Shigeharu" uniqKey="Wakana S" first="Shigeharu" last="Wakana">Shigeharu Wakana</name><affiliation wicri:level="1"><nlm:affiliation>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074</wicri:regionArea><wicri:noRegion>Ibaraki 305-0074</wicri:noRegion></affiliation></author><author><name sortKey="Warren, Jonathan" sort="Warren, Jonathan" uniqKey="Warren J" first="Jonathan" last="Warren">Jonathan Warren</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Wendling, Olivia" sort="Wendling, Olivia" uniqKey="Wendling O" first="Olivia" last="Wendling">Olivia Wendling</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="West, David B" sort="West, David B" uniqKey="West D" first="David B" last="West">David B. West</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital Oakland Research Institute, Oakland, California 94609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital Oakland Research Institute, Oakland, California 94609</wicri:regionArea><wicri:noRegion>California 94609</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Leeyean" sort="Wong, Leeyean" uniqKey="Wong L" first="Leeyean" last="Wong">Leeyean Wong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Yoshiki, Atsushi" sort="Yoshiki, Atsushi" uniqKey="Yoshiki A" first="Atsushi" last="Yoshiki">Atsushi Yoshiki</name><affiliation wicri:level="1"><nlm:affiliation>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074</wicri:regionArea><wicri:noRegion>Ibaraki 305-0074</wicri:noRegion></affiliation></author><author><name sortKey="Macarthur, Daniel G" sort="Macarthur, Daniel G" uniqKey="Macarthur D" first="Daniel G" last="Macarthur">Daniel G. Macarthur</name><affiliation wicri:level="1"><nlm:affiliation>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Tocchini Valentini, Glauco P" sort="Tocchini Valentini, Glauco P" uniqKey="Tocchini Valentini G" first="Glauco P" last="Tocchini-Valentini">Glauco P. Tocchini-Valentini</name><affiliation wicri:level="1"><nlm:affiliation>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015</wicri:regionArea><wicri:noRegion>Monterotondo Scalo I-00015</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="1"><nlm:affiliation>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061</wicri:regionArea><wicri:noRegion>Nanjing 210061</wicri:noRegion></affiliation></author><author><name sortKey="Flicek, Paul" sort="Flicek, Paul" uniqKey="Flicek P" first="Paul" last="Flicek">Paul Flicek</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Bradley, Allan" sort="Bradley, Allan" uniqKey="Bradley A" first="Allan" last="Bradley">Allan Bradley</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Skarnes, William C" sort="Skarnes, William C" uniqKey="Skarnes W" first="William C" last="Skarnes">William C. Skarnes</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Justice, Monica J" sort="Justice, Monica J" uniqKey="Justice M" first="Monica J" last="Justice">Monica J. Justice</name><affiliation wicri:level="1"><nlm:affiliation>The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, Toronto, Ontario M5G 1X8</wicri:regionArea><wicri:noRegion>Ontario M5G 1X8</wicri:noRegion></affiliation></author><author><name sortKey="Parkinson, Helen E" sort="Parkinson, Helen E" uniqKey="Parkinson H" first="Helen E" last="Parkinson">Helen E. Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Mark" sort="Moore, Mark" uniqKey="Moore M" first="Mark" last="Moore">Mark Moore</name><affiliation wicri:level="1"><nlm:affiliation>IMPC, San Anselmo, California 94960, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>IMPC, San Anselmo, California 94960</wicri:regionArea><wicri:noRegion>California 94960</wicri:noRegion></affiliation></author><author><name sortKey="Wells, Sara" sort="Wells, Sara" uniqKey="Wells S" first="Sara" last="Wells">Sara Wells</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Braun, Robert E" sort="Braun, Robert E" uniqKey="Braun R" first="Robert E" last="Braun">Robert E. Braun</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="Svenson, Karen L" sort="Svenson, Karen L" uniqKey="Svenson K" first="Karen L" last="Svenson">Karen L. Svenson</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author><author><name sortKey="De Angelis, Martin Hrabe" sort="De Angelis, Martin Hrabe" uniqKey="De Angelis M" first="Martin Hrabe" last="De Angelis">Martin Hrabe De Angelis</name><affiliation wicri:level="1"><nlm:affiliation>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764</wicri:regionArea><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>85764</wicri:noRegion><wicri:noRegion>Neuherberg 85764</wicri:noRegion></affiliation></author><author><name sortKey="Herault, Yann" sort="Herault, Yann" uniqKey="Herault Y" first="Yann" last="Herault">Yann Herault</name><affiliation wicri:level="3"><nlm:affiliation>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Mohun, Tim" sort="Mohun, Tim" uniqKey="Mohun T" first="Tim" last="Mohun">Tim Mohun</name><affiliation wicri:level="1"><nlm:affiliation>The Francis Crick Institute Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW1 1AT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Francis Crick Institute Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW1 1AT</wicri:regionArea><wicri:noRegion>London NW1 1AT</wicri:noRegion></affiliation></author><author><name sortKey="Mallon, Ann Marie" sort="Mallon, Ann Marie" uniqKey="Mallon A" first="Ann-Marie" last="Mallon">Ann-Marie Mallon</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Henkelman, R Mark" sort="Henkelman, R Mark" uniqKey="Henkelman R" first="R Mark" last="Henkelman">R Mark Henkelman</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Steve D M" sort="Brown, Steve D M" uniqKey="Brown S" first="Steve D M" last="Brown">Steve D M. Brown</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD</wicri:regionArea><wicri:noRegion>Oxfordshire OX11 0RD</wicri:noRegion></affiliation></author><author><name sortKey="Adams, David J" sort="Adams, David J" uniqKey="Adams D" first="David J" last="Adams">David J. Adams</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Lloyd, K C Kent" sort="Lloyd, K C Kent" uniqKey="Lloyd K" first="K C Kent" last="Lloyd">K C Kent Lloyd</name><affiliation wicri:level="1"><nlm:affiliation>Mouse Biology Program, University of California, Davis, California 95618, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mouse Biology Program, University of California, Davis, California 95618</wicri:regionArea><wicri:noRegion>California 95618</wicri:noRegion></affiliation></author><author><name sortKey="Mckerlie, Colin" sort="Mckerlie, Colin" uniqKey="Mckerlie C" first="Colin" last="Mckerlie">Colin Mckerlie</name><affiliation wicri:level="1"><nlm:affiliation>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7</wicri:regionArea><wicri:noRegion>Ontario M5T 3H7</wicri:noRegion></affiliation></author><author><name sortKey="Beaudet, Arthur L" sort="Beaudet, Arthur L" uniqKey="Beaudet A" first="Arthur L" last="Beaudet">Arthur L. Beaudet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Bu An, Maja" sort="Bu An, Maja" uniqKey="Bu An M" first="Maja" last="Bu An">Maja Bu An</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Genetics and Psychiatry, Perlman School of Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics and Psychiatry, Perlman School of Medicine, University of Pennsylvania, Philadelphia Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Philadelphia Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Stephen A" sort="Murray, Stephen A" uniqKey="Murray S" first="Stephen A" last="Murray">Stephen A. Murray</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, Maine 04609</wicri:regionArea><wicri:noRegion>Maine 04609</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature</title><idno type="eISSN">1476-4687</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Conserved Sequence (genetics)</term><term>Disease</term><term>Embryo, Mammalian (embryology)</term><term>Embryo, Mammalian (metabolism)</term><term>Genes, Essential (genetics)</term><term>Genes, Lethal (genetics)</term><term>Genome-Wide Association Study</term><term>High-Throughput Screening Assays</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Mutation (genetics)</term><term>Penetrance</term><term>Phenotype</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Sequence Homology</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Embryo, Mammalian</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conserved Sequence</term><term>Genes, Essential</term><term>Genes, Lethal</term><term>Mutation</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Embryo, Mammalian</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease</term><term>Genome-Wide Association Study</term><term>High-Throughput Screening Assays</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Penetrance</term><term>Phenotype</term><term>Sequence Homology</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,000 knockout mouse lines, here we identify 410 lethal genes during the production of the first 1,751 unique gene knockouts. Using a standardized phenotyping platform that incorporates high-resolution 3D imaging, we identify phenotypes at multiple time points for previously uncharacterized genes and additional phenotypes for genes with previously reported mutant phenotypes. Unexpectedly, our analysis reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background. In addition, we show that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Canada</li><li>France</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Dickinson, Mary E" sort="Dickinson, Mary E" uniqKey="Dickinson M" first="Mary E" last="Dickinson">Mary E. Dickinson</name></noRegion><name sortKey="Baker, Candice N" sort="Baker, Candice N" uniqKey="Baker C" first="Candice N" last="Baker">Candice N. Baker</name><name sortKey="Beaudet, Arthur L" sort="Beaudet, Arthur L" uniqKey="Beaudet A" first="Arthur L" last="Beaudet">Arthur L. Beaudet</name><name sortKey="Bower, Lynette" sort="Bower, Lynette" uniqKey="Bower L" first="Lynette" last="Bower">Lynette Bower</name><name sortKey="Braun, Robert E" sort="Braun, Robert E" uniqKey="Braun R" first="Robert E" last="Braun">Robert E. Braun</name><name sortKey="Bu An, Maja" sort="Bu An, Maja" uniqKey="Bu An M" first="Maja" last="Bu An">Maja Bu An</name><name sortKey="Caddle, L Brianna" sort="Caddle, L Brianna" uniqKey="Caddle L" first="L Brianna" last="Caddle">L Brianna Caddle</name><name sortKey="Clary, Dave" sort="Clary, Dave" uniqKey="Clary D" first="Dave" last="Clary">Dave Clary</name><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J" last="Daly">Mark J. Daly</name><name sortKey="Denegre, James M" sort="Denegre, James M" uniqKey="Denegre J" first="James M" last="Denegre">James M. Denegre</name><name sortKey="Dolan, Mary E" sort="Dolan, Mary E" uniqKey="Dolan M" first="Mary E" last="Dolan">Mary E. Dolan</name><name sortKey="Edie, Sarah M" sort="Edie, Sarah M" uniqKey="Edie S" first="Sarah M" last="Edie">Sarah M. Edie</name><name sortKey="Gallegos, Juan" sort="Gallegos, Juan" uniqKey="Gallegos J" first="Juan" last="Gallegos">Juan Gallegos</name><name sortKey="Hsu, Chih Wei" sort="Hsu, Chih Wei" uniqKey="Hsu C" first="Chih-Wei" last="Hsu">Chih-Wei Hsu</name><name sortKey="Ji, Xiao" sort="Ji, Xiao" uniqKey="Ji X" first="Xiao" last="Ji">Xiao Ji</name><name sortKey="Kalaga, Sowmya" sort="Kalaga, Sowmya" uniqKey="Kalaga S" first="Sowmya" last="Kalaga">Sowmya Kalaga</name><name sortKey="Keith, Lance C" sort="Keith, Lance C" uniqKey="Keith L" first="Lance C" last="Keith">Lance C. Keith</name><name sortKey="Lanoue, Louise" sort="Lanoue, Louise" uniqKey="Lanoue L" first="Louise" last="Lanoue">Louise Lanoue</name><name sortKey="Lek, Monkol" sort="Lek, Monkol" uniqKey="Lek M" first="Monkol" last="Lek">Monkol Lek</name><name sortKey="Lloyd, K C Kent" sort="Lloyd, K C Kent" uniqKey="Lloyd K" first="K C Kent" last="Lloyd">K C Kent Lloyd</name><name sortKey="Macarthur, Daniel G" sort="Macarthur, Daniel G" uniqKey="Macarthur D" first="Daniel G" last="Macarthur">Daniel G. Macarthur</name><name sortKey="Mcelwee, Melissa L" sort="Mcelwee, Melissa L" uniqKey="Mcelwee M" first="Melissa L" last="Mcelwee">Melissa L. Mcelwee</name><name sortKey="Moore, Mark" sort="Moore, Mark" uniqKey="Moore M" first="Mark" last="Moore">Mark Moore</name><name sortKey="Murray, Stephen A" sort="Murray, Stephen A" uniqKey="Murray S" first="Stephen A" last="Murray">Stephen A. Murray</name><name sortKey="Peterson, Kevin A" sort="Peterson, Kevin A" uniqKey="Peterson K" first="Kevin A" last="Peterson">Kevin A. Peterson</name><name sortKey="Rowland, Douglas J" sort="Rowland, Douglas J" uniqKey="Rowland D" first="Douglas J" last="Rowland">Douglas J. Rowland</name><name sortKey="Samocha, Kaitlin E" sort="Samocha, Kaitlin E" uniqKey="Samocha K" first="Kaitlin E" last="Samocha">Kaitlin E. Samocha</name><name sortKey="Seavitt, John R" sort="Seavitt, John R" uniqKey="Seavitt J" first="John R" last="Seavitt">John R. Seavitt</name><name sortKey="Svenson, Karen L" sort="Svenson, Karen L" uniqKey="Svenson K" first="Karen L" last="Svenson">Karen L. Svenson</name><name sortKey="Trainor, Amanda G" sort="Trainor, Amanda G" uniqKey="Trainor A" first="Amanda G" last="Trainor">Amanda G. Trainor</name><name sortKey="West, David B" sort="West, David B" uniqKey="West D" first="David B" last="West">David B. West</name><name sortKey="Wong, Leeyean" sort="Wong, Leeyean" uniqKey="Wong L" first="Leeyean" last="Wong">Leeyean Wong</name></country><country name="Canada"><noRegion><name sortKey="Flenniken, Ann M" sort="Flenniken, Ann M" uniqKey="Flenniken A" first="Ann M" last="Flenniken">Ann M. Flenniken</name></noRegion><name sortKey="Adissu, Hibret" sort="Adissu, Hibret" uniqKey="Adissu H" first="Hibret" last="Adissu">Hibret Adissu</name><name sortKey="Henkelman, R Mark" sort="Henkelman, R Mark" uniqKey="Henkelman R" first="R Mark" last="Henkelman">R Mark Henkelman</name><name sortKey="Justice, Monica J" sort="Justice, Monica J" uniqKey="Justice M" first="Monica J" last="Justice">Monica J. Justice</name><name sortKey="Mckerlie, Colin" sort="Mckerlie, Colin" uniqKey="Mckerlie C" first="Colin" last="Mckerlie">Colin Mckerlie</name><name sortKey="Newbigging, Susan" sort="Newbigging, Susan" uniqKey="Newbigging S" first="Susan" last="Newbigging">Susan Newbigging</name><name sortKey="Nutter, Lauryl M J" sort="Nutter, Lauryl M J" uniqKey="Nutter L" first="Lauryl M J" last="Nutter">Lauryl M J. Nutter</name><name sortKey="Wong, Michael D" sort="Wong, Michael D" uniqKey="Wong M" first="Michael D" last="Wong">Michael D. Wong</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Teboul, Lydia" sort="Teboul, Lydia" uniqKey="Teboul L" first="Lydia" last="Teboul">Lydia Teboul</name></noRegion><name sortKey="Adams, David J" sort="Adams, David J" uniqKey="Adams D" first="David J" last="Adams">David J. 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Parkinson</name><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><name sortKey="Ryder, Edward" sort="Ryder, Edward" uniqKey="Ryder E" first="Edward" last="Ryder">Edward Ryder</name><name sortKey="Skarnes, William C" sort="Skarnes, William C" uniqKey="Skarnes W" first="William C" last="Skarnes">William C. 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White</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Weninger, Wolfgang J" sort="Weninger, Wolfgang J" uniqKey="Weninger W" first="Wolfgang J" last="Weninger">Wolfgang J. Weninger</name></region></country><country name="Italie"><noRegion><name sortKey="Chiani, Francesco" sort="Chiani, Francesco" uniqKey="Chiani F" first="Francesco" last="Chiani">Francesco Chiani</name></noRegion><name sortKey="Gambadoro, Alessia" sort="Gambadoro, Alessia" uniqKey="Gambadoro A" first="Alessia" last="Gambadoro">Alessia Gambadoro</name><name sortKey="Tocchini Valentini, Glauco P" sort="Tocchini Valentini, Glauco P" uniqKey="Tocchini Valentini G" first="Glauco P" last="Tocchini-Valentini">Glauco P. Tocchini-Valentini</name></country><country name="Allemagne"><noRegion><name sortKey="Fuchs, Helmut" sort="Fuchs, Helmut" uniqKey="Fuchs H" first="Helmut" last="Fuchs">Helmut Fuchs</name></noRegion><name sortKey="De Angelis, Martin Hrabe" sort="De Angelis, Martin Hrabe" uniqKey="De Angelis M" first="Martin Hrabe" last="De Angelis">Martin Hrabe De Angelis</name><name sortKey="Gailus Durner, Valerie" sort="Gailus Durner, Valerie" uniqKey="Gailus Durner V" first="Valerie" last="Gailus-Durner">Valerie Gailus-Durner</name><name sortKey="Marschall, Susan" sort="Marschall, Susan" uniqKey="Marschall S" first="Susan" last="Marschall">Susan Marschall</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Guo, Shiying" sort="Guo, Shiying" uniqKey="Guo S" first="Shiying" last="Guo">Shiying Guo</name></noRegion><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></country><country name="France"><region name="Grand Est"><name sortKey="Mark, Manuel" sort="Mark, Manuel" uniqKey="Mark M" first="Manuel" last="Mark">Manuel Mark</name></region><name sortKey="Herault, Yann" sort="Herault, Yann" uniqKey="Herault Y" first="Yann" last="Herault">Yann Herault</name><name sortKey="Selloum, Mohammed" sort="Selloum, Mohammed" uniqKey="Selloum M" first="Mohammed" last="Selloum">Mohammed Selloum</name><name sortKey="Wendling, Olivia" sort="Wendling, Olivia" uniqKey="Wendling O" first="Olivia" last="Wendling">Olivia Wendling</name></country><country name="Japon"><noRegion><name sortKey="Tamura, Masaru" sort="Tamura, Masaru" uniqKey="Tamura M" first="Masaru" last="Tamura">Masaru Tamura</name></noRegion><name sortKey="Wakana, Shigeharu" sort="Wakana, Shigeharu" uniqKey="Wakana S" first="Shigeharu" last="Wakana">Shigeharu Wakana</name><name sortKey="Yoshiki, Atsushi" sort="Yoshiki, Atsushi" uniqKey="Yoshiki A" first="Atsushi" last="Yoshiki">Atsushi Yoshiki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000037 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000037 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= pubmed:27626380
|texte= High-throughput discovery of novel developmental phenotypes.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:27626380" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |